Female Reproductive System Clinical Pathologic Correlation

Female Reproductive System Clinical Pathologic Correlation

​This brief video notes that diseases of the female reproductive system can be organized by anatomy and understood that they would be seen this way in the physical examination.

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Female Reproductive System Structure and Anatomy

Female Reproductive Endocrinology: Structure and Function

​Endocrine systems should be learned as feedback loops. For the female reproductive endocrinology, this requires an understanding of the menstrual cycle and the feedback loops of H > P > O > E. The best way to learn this is through an understanding of clinical testing (serum TSH and progesterone) and drugs (leuprolide, COCP, clomiphene and spironolactone).

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Female Reproductive Structure

Discussion emphasizes the structure of pelvic support for the internal genitalia, including the diaphragms, ligaments and perineal body. This is correlated to uterine prolapse and urinary incontinence. External and internal genital anatomy is reviewed with emphasis on the histology and its correlation to neoplasia and infections.

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Female Reproductive System Pathology

Female Reproductive System Pathology: External Genitalia

The first of two lectures on female reproductive system pathology covers diseases of the external genitalia. These include rashes and masses of the vulva and infections  that have rashes or vaginal discharges.

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Female Reproductive System Pathology: Internal Genitalia

The second of two lectures covers the internal genitalia. It discusses the correlation of uterine bleeding pathology to reproductive age. The endometrial diseases of DUB, endometriosis and endometrial hyperplasias are reviewed. Ectopic pregnancy is discussed. In the ovary, PCOS is reviewed, together with pathophysiologic principles that underlie the management of ovarian cysts.

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Female Reproductive System Neoplasia

Female Reproductive System Neoplasia: Vulva and Cervix

The key principles of vulvar squamous cell carcinoma are reviewed. As HPV is the cause of >99% of cervical carcinomas, the natural history of HPV is correlated to the development of neoplasia and patient care, Vaccines are briefly reviewed.

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Female Reproductive System Neoplasia: Uterus and Ovary

The two major types of endometrial carcinoma are discussed, including their key molecular defects. Four major ovarian neoplasms  derive from the surface epithelium, germ cells, granular cells and stroma, as well as metastases. Serous carcinoma is presented as the model disease, with discussion of BRCA testing.

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Female Reproductive System Infertility

Female Reproductive System Amenorrhea and Infertility

This lecture gives the algorithmic approach to the investigation of primary and secondary arrhythmia together with an approach to infertility. Primary amenorrhea includes Kallman, Turner, Mullerian agenesis (RKH), androgen insensitivity syndromes together with the outflow obstructions. Secondary amenorrhea includes PCOS, hypothalamus disorders, hyperprolactinemias and ovarian failure. Infertility adds in chronic PID and endometriosis.

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