Development of Immune Memory Quiz

A 10-year-old male is referred for immunologic workup because his parents are concerned about enlarging, disfiguring lumps on his neck.   History is significant for episodes of pneumococcal sepsis, vasculitis and bleeding disorders.  Examination is significant for dramatic enlargement of cervical, axillary, femoral and inguinal lymph nodes.  Biopsy of one of the cervical nodes shows extreme hypercellularity in paracortical areas, although the dividing cells are normal in morphology.  The molecule most likely to be absent in this case normally controls which of the following:

In a normal childhood vaccination protocol, the first dose of Haemophilus influenzae vaccine (HiB) is delivered at 2 months, with boosters at 4, 6, and 12 months.  At 12 months, an additional variety of vaccines are administered for the first dose, one of which is the killed vaccine against hepatitis A virus (HAV).  Both of these vaccines are administered by intramuscular injection.  If the child’s responses against HiB and HAV were measured one day following the inoculation of the first dose of HAV, which of the following would be true?

The rotavirus vaccine is administered in infancy, with first dose at 2 months and boosters at 4 and 6 months.  It is a live, attenuated vaccine which is administered orally.  At the end of a successful series, where would the majority of memory cells be expected to reside?